Dibenamine hydrochloride → 1-(N,N-dibenzylamino)-2-(4-benzyloxyphenoxy)-ethane

HRID 1974374

반응식

HRID 1974374 반응식
Cl.[CH2:2]([N:9]([CH2:17][CH2:18]Cl)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(#N)C>[CH2:2]([N:9]([CH2:17][CH2:18][O:40][C:37]1[CH:36]=[CH:35][C:34]([O:33][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:39][CH:38]=1)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 5925Dibenamine hydrochlorideHCID 7638MonobenzoneHCID 11430Potassium Carbonate

생성물 1

HCID 129226391-(N,N-dibenzylamino)-2-(4-benzyloxyphenoxy)-ethane

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The material given in Example 1 was prepared in accordance with the following. 20.0 g. of N,N-dibenzyl-2-chloroethylamine hydrochloride and 27.6 g of potassium carbonate were mixed in 250 ml of acetonitrile. The mixture was refluxed for 15 min. and 13.8 g of 4-benzyloxyphenol were added, whereupon the mixture was refluxed for 5 hours while stirred. After filtration and evaporation the residue was recrystallized from petroleum ether. 18.4 g of 1-(N,N-dibenzylamino)-2-(4-benzyloxyphenoxy)-ethane was obtained. The structure was determined using NMR.

후처리

  1. customwas prepared in accordance with the following
  2. temperatureThe mixture was refluxed for 15 min.
  3. temperaturewas refluxed for 5 hours
  4. filtrationAfter filtration and evaporation the residue
  5. customwas recrystallized from petroleum ether

출처 및 근거

ORD 기록
ord-e9908ede3f324cf68bb2cbda3b5b309c
출처 데이터셋
uspto-grants-1976_12
특허 번호
US04000313

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