Water → 4-(Pyridin-2-yl)butan-1-amine
반응식
[C:1]([CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1참가 물질
6
실험 절차
2-(3-cyanopropyl)pyridine (14.6 g) in dry ether (100 ml) is added dropwise to a stirred suspension of lithium aluminium hydride (9.5 g) in dry ether (300 ml). The mixture is heated under reflux for 3 hours, cooled and treated successively with water, aqueous sodium hydroxide and water. Extraction with chloroform, followed by fractionation affords 2-(4-aminobutyl)pyridine (6.7 g), b.p. 100°-101° C/1.0 mm.
후처리
- temperatureThe mixture is heated
- temperatureunder reflux for 3 hours
- temperaturecooled
- extractionExtraction with chloroform
출처 및 근거
- ORD 기록
- ord-15fd66a59c8d4a16af08896d5f68c0c2
- 출처 데이터셋
- uspto-grants-1976_12
- 특허 번호
- US04000302
반응 노트
불러오는 중…