참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ibuprofen, (+-)- | HCID 3672 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-(4-Isobutylphenyl)propiononitrile | HCID 108374 | — |
| 생성물 | Dexibuprofen | HCID 39912 | — |
반응 단계
One ml of the reaction solution containing 100 μmol of potassium phosphate buffer solution (pH 8.0), 4.77 μmol of 2-(4'-isobutylphenyl)propionitrile and 0.02 unit of nitrilase was thoroughly shaken at 32° C. to carry out the reaction. The amounts of 2-(4'-isobutylphenyl)-propionitrile, 2-(4'-isobutylphenyl)propionic acid and ammonia for each reaction time were determined. The results are shown in the Figure. The optical purity of the formed S-(+)-2-(4'-isobutylphenyl)propionic acid was 98% for 6 hours, 96% for 24 hours and 95% for 40 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05283193 |
|---|
| 출처 데이터셋 | uspto-grants-1994_02 |
|---|
| ORD ID | ord-a910e50445e34748afab0963e9b6fb00 |
|---|
| 출처 메모 | uspto-grants-1994_02 |
|---|
