Sodium Hydroxide → 4-(2-Methyl-1H-indol-3-yl)butanoic acid

HRID 1974560노트

반응식

HRID 1974560 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=[CH:6][CH:5]=2.[OH-].[Na+]>CO>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=[CH:6][CH:5]=2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10609557Methyl 4-(2-methylindol-3-yl)butyrate

생성물 1

HCID 150472604-(2-Methyl-1H-indol-3-yl)butanoic acid수율 79.4%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
20 °C

실험 절차

To a solution of methyl 4-(2-methylindol-3-yl)-butyrate (1.65 g) in methanol (50 ml) was added 1N aqueous sodium hydroxide (18 ml) at 20° C. and the mixture was stirred at 20° C. for 3 hours. After evaporation of the solvent, the residue was poured into a mixture of ethyl acetate and 1N hydrochloric acid. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. After evaporation of solvent, the crystalline residue was washed with hexane to give 4(2-methylindol-3-yl)butyric acid (1.23 g) as reddish brown crystals.

후처리

  1. customAfter evaporation of the solvent
  2. additionthe residue was poured into a mixture of ethyl acetate and 1N hydrochloric acid
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over magnesium sulfate
  6. customAfter evaporation of solvent
  7. washthe crystalline residue was washed with hexane

출처 및 근거

ORD 기록
ord-01a2cf39deea47b2a9d5f4fa99c3a8cf
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283251

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