(+-)-2-Butanol → 2-[(Butan-2-yl)oxy]-3,5,6-trichlorocyclohexa-2,5-diene-1,4-dione

HRID 1974678노트

반응식

HRID 1974678 반응식
[C:1]1(Cl)[C:7](=[O:8])[C:6]([Cl:9])=[C:5]([Cl:10])[C:3](=[O:4])[C:2]=1[Cl:11].C(=O)([O-])O.[Na+].[CH3:18][CH:19]([OH:22])[CH2:20][CH3:21]>CCC(C)=O>[Cl:9][C:6]1[C:7]([C:1]([O:22][CH:19]([CH2:20][CH3:21])[CH3:18])=[C:2]([Cl:11])[C:3](=[O:4])[C:5]=1[Cl:10])=[O:8]

참가 물질

5

반응물 3

HCID 6568(+-)-2-ButanolHCID 8371ChloranilHCID 516892Sodium Bicarbonate

생성물 1

HCID 191021892-[(Butan-2-yl)oxy]-3,5,6-trichlorocyclohexa-2,5-diene-1,4-dione수율 86%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Chloranil (12.3 parts) was dissolved in MEK (300 parts) before adding sodium hydrogen carbonate (8 parts). Aqueous butan-2-ol (50 parts, 1:1) was then added and the mixture was stirred at room temperature until no starting material remained. At the end of the reaction the filtered solution was shown by HPLC to contain 86% title product. The product was used in subsequent reactions without isolation.

후처리

  1. customAt the end of the reaction the filtered solution

출처 및 근거

ORD 기록
ord-02602ba1a7394d668750437e19740dd2
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283355

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