Hydrochloric Acid → 2-(4-Fluorophenylthio)-6-fluorobenzoic acid

HRID 1974755노트

반응식

HRID 1974755 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[C:16]2[O:17]CC(C)(C)N=2)=[CH:4][CH:3]=1.Cl.[OH2:24]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[C:16]([OH:17])=[O:24])=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 191022272-[2-(4-Fluorophenylthio)-6-fluorophenyl]-4,4-dimethyloxazoline

생성물 1

HCID 191022242-(4-Fluorophenylthio)-6-fluorobenzoic acid

실험 절차

The compound 2-[2-(4-fluorophenylthio)-6-fluorophenyl]-4,4-dimethyloxazoline (5.0 g, 15.66 mmol) is added to 310 ml of a 4.5N HCl solution in water and is refluxed overnight. The cooled reaction mixture is extracted twice with ethyl acetate. The extracts are washed with water and then brine and dried over MgSO4 to afford the subtitle compound.

후처리

  1. temperatureis refluxed overnight
  2. customThe cooled reaction mixture
  3. extractionis extracted twice with ethyl acetate
  4. washThe extracts are washed with water
  5. dry with materialbrine and dried over MgSO4

출처 및 근거

ORD 기록
ord-3f64436bf89c4a4e90f95fe819ca203f
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283361

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