Hydrogen Bromide → 1-[2-(4-Fluorophenylthio)-6-fluorophenyl]3-bromoprop-1-ene

HRID 1974759노트

반응식

HRID 1974759 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[CH:16](O)[CH:17]=[CH2:18])=[CH:4][CH:3]=1.C(OCC)C.[BrH:25].O>CCCCCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[CH:16]=[CH:17][CH2:18][Br:25])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 260Hydrogen BromideHCID 962WaterHCID 3283Diethyl EtherHCID 191022051-(2-(4-Fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol

생성물 1

HCID 540068731-[2-(4-Fluorophenylthio)-6-fluorophenyl]3-bromoprop-1-ene

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

1-(2-(4-fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol (2.29 g, 8.23 mmol) is dissolved in 10 ml of hexane and 10 ml of diethyl ether and cooled in an ice bath. Concentrated HBr acid (4.6 ml, 41.2 mmol) is then added dropwise and the reaction mixture is stirred vigorously for 5 hours at room temperature. The reaction mixture is then poured into water and extracted twice with diethyl ether. The extracts are washed with water and then brine and dried over MgSO4 to afford the subtitle compound.

후처리

  1. extractionextracted twice with diethyl ether
  2. washThe extracts are washed with water
  3. dry with materialbrine and dried over MgSO4

출처 및 근거

ORD 기록
ord-51a5f4a8e8dc4914ada856c72ccb657d
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283361

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