Hydrochloric Acid → HCID 53978363, 화합물

HRID 1974797노트

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HRID 1974797 반응식
[C:1]([NH:14][CH2:15][CH2:16][C:17]([OH:19])=O)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(Cl)([Cl:22])=O.S(=O)=O.Cl>C(Cl)Cl>[C:1]([NH:14][CH2:15][CH2:16][C:17]([Cl:22])=[O:19])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 24386Thionyl ChlorideHCID 3262167Lauroyl beta-alanine

생성물 1

HCID 53978363HCID 53978363, 화합물수율 101%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
20 °C

실험 절차

46.8 g of N-lauroyl-β-alanine was dispersed in 155 ml of methylene chloride. Then, 24.8 g of thionyl chloride was added thereto within 10 minutes under stirring while maintaining the temperature of the mixture at 20° C. After the completion of the addition, the mixture was stirred at the same temperature for 30 minutes so as to complete the reaction. When the reaction solution thus obtained was analyzed by infrared spectroscopy, a peak at 1695 cm-1 due to carboxylic acid (--COOH) disappeared while a new peak due to acid chloride (--COCl) was formed at 1782 cm-1. These facts indicated that an acid chloride was obtained. Then, the methylene chloride employed as the solvent and side products (sulfur dioxide and hydrogen chloride) were distilled off from the reaction mixture under reduced pressure. Thus, 50.5 g of N-lauroyl-3-aminopropionic acid chloride was obtained.

후처리

  1. additionAfter the completion of the addition
  2. stirringthe mixture was stirred at the same temperature for 30 minutes so as
  3. customthe reaction
  4. customWhen the reaction solution thus obtained
  5. customwas formed at 1782 cm-1
  6. customwas obtained
  7. distillationwere distilled off from the reaction mixture under reduced pressure

출처 및 근거

ORD 기록
ord-9a7a9e8a9afd4a8f95c3143fa88bde8a
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284602

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