Hydrochloric Acid → 4-Hydroxy-4-methylaminomethylpiperidine dihydrochloride

HRID 1974870노트

반응식

HRID 1974870 반응식
[OH:1][C:2]1([CH2:13][NH:14][CH3:15])[CH2:7][CH2:6][N:5](C(OCC)=O)[CH2:4][CH2:3]1.[ClH:16]>>[ClH:16].[ClH:16].[OH:1][C:2]1([CH2:13][NH:14][CH3:15])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 19382193HCID 19382193, 화합물

생성물 1

HCID 193821784-Hydroxy-4-methylaminomethylpiperidine dihydrochloride

실험 절차

3 g (13.9 mmol) of ethyl 4-hydroxy-4-methylaminomethylpiperidine-1-carboxylate are heated overnight under reflux with 30 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are stirred with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

후처리

  1. concentrationThe product is concentrated
  2. filtrationfiltered off with suction
  3. dry with materialdried in a vacuum desiccator over P4O10

출처 및 근거

ORD 기록
ord-2cd26c5cef15468881d1ed8a2153964b
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284842

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