Diethyl Oxalate → Thieno[2,3-b]pyrazine-2,3(1H,4H)-dione
반응식
[S:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](OC(C)(C)C)=[O:8])=[C:2]1[NH:14][C:15]([O:17]C(C)(C)C)=O.C(OCC)(=O)C(OCC)=O>C(O)(=O)C>[NH:6]1[C:7](=[O:8])[C:15](=[O:17])[NH:14][C:2]2[S:1][CH:5]=[CH:4][C:3]1=2참가 물질
4
실험 절차
A mixture of di-t-butyl thiophene-2,3-dicarbamate (1.53 g, 4.87 mmol), diethyl oxalate (15 ml) and acetic acid (15 ml) was refluxed for 48 hours. The precipitate was filtered off, washed with water and dried to yield 0.64 g (78%) of the title compound. M.p. >340° C. 1H-NMR (DMSO-d6, δ): 6.74 (d, 1H), 7.13 (d, 1H), 12.28 (s, 1H).
후처리
- temperaturewas refluxed for 48 hours
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-641f15be9ad14c66bd62c2230aecea1a
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05284847
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