Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1975004노트

반응식

HRID 1975004 반응식
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 19100972Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

생성물 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The batch is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

후처리

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationdistilled

출처 및 근거

ORD 기록
ord-97a973d345d248c7bc927724b14b2d0f
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284855

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