HCID 19100941, 화합물 → 5-Chloro-2-methyl-2,7-diazabicyclo[3.3.0]octane
반응식
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2참가 물질
3
실험 절차
9.3 g (40 mmol) of ethyl 5-chloro-2-methyl-2,7-diazabicyclo[3.3. 0 ]octane-7-carboxylate are refluxed overnight together with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, the concentrate is taken up in 30 ml of water, and this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 ml portions of chloroform. The extracts are dried over potassium carbonate, concentrated and distilled.
후처리
- concentrationThe mixture is concentrated
- extractionextracted five times
- dry with materialThe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-c6bfc97754184e48b85de62f7e123418
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05284855
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