HCID 19100959, 화합물 → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1975013노트

반응식

HRID 1975013 반응식
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

참가 물질

3

반응물 1

HCID 19100959HCID 19100959, 화합물

생성물 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0 ]octane-7-carboxylate together with 30 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 30 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 mi portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-3b7d2e3ebd244f23b5466b3961aa741e
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284855

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