Potassium Carbonate → Decahydropyrrolo[3,4-b]pyrrolizine

HRID 1975015노트

반응식

HRID 1975015 반응식
[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>Cl>[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 53870311Ethyl 1,4-diazatricyclo[6.3.0.02,6]undecane-4-carboxylate

생성물 1

HCID 16227934Decahydropyrrolo[3,4-b]pyrrolizine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9 g (40 mmol) of ethyl 1,4-diazatricyclo[6.3.0.02,6 ]undecane-4-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-9ae9d580c28247e78504406a9ea74868
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284855

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