HCID 19100973, 화합물 → HCID 19100943, 화합물

HRID 1975028노트

반응식

HRID 1975028 반응식
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

참가 물질

3

반응물 1

HCID 19100973HCID 19100973, 화합물

생성물 1

HCID 19100943HCID 19100943, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 100 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 20 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-15f90691a1d34175a558224d4324b463
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284855

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