Hydrogen Bromide → HCID 13487107, 화합물

HRID 1975413노트

반응식

HRID 1975413 반응식
[ClH:1].C[O:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C@H:8]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[C@@H:9]2[CH3:14].Br>CO>[ClH:1].[OH:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C@H:8]([N:15]([CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH3:21])[C@@H:9]2[CH3:14]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 13487103HCID 13487103, 화합물

생성물 1

HCID 13487107HCID 13487107, 화합물수율 72.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

(-)-cis-5-Methoxy-1-methyl-2-(di-n-propylamino)tetralin hydrochloride (0.37 g, 0.0012 mol) was treated with 48% HBr (15 ml) as described above to give (-)-cis-5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin hydrochloride (0.26 g, 55%) m.p. 228°-229° C., [α]D22 =-50.1 (c=1.1, CH3OH).

출처 및 근거

ORD 기록
ord-b2680bcd1dc74f398ef6e7420af435dc
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05286747

반응 노트

불러오는 중…