Ciprofloxacin → Ciprofloxacin Hydrochloride Anhydrous

HRID 1975618

반응식

HRID 1975618 반응식
[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:24][CH2:23]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:6]=1[F:7].[Na+].[Cl-:26]>O>[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:23][CH2:24]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[C:6]=1[F:7].[ClH:26]

참가 물질

4

반응물 2

HCID 2764Ciprofloxacin4회HCID 5234Sodium Chloride

생성물 1

HCID 62999Ciprofloxacin Hydrochloride Anhydrous

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To demonstrate the release of the ciprofloxacin from the cryogel in a simulated body fluid environment, the cryogel/ciprofloxacin disk was immersed in 1.0 ml portions of 0.9% NaCl in distilled water for 1 hour, after which the procedure was repeated. HPLC analyses of the saline extracts for ciprofloxacin were made. The pH of these saline extracts was found to be 5.5. The initial content of ciprofloxacin in the disk was estimated to be 15 mg. The results are shown in Table 9.

출처 및 근거

ORD 기록
ord-88db685a06644598b4d5911151f8d68e
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05288503

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