Hydrazine hydrate (1:1) → [4'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone

HRID 1975657

반응식

HRID 1975657 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.O.[NH2:22][NH2:23]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:22][NH2:23])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 98172164'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone

생성물 1

HCID 85677185[4'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

5.1 g (18.1 mmol) of 4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone was dissolved in 100 ml of ethanol, and 8.8 ml (181 mmol) of hydrazine monohydrate was added thereto. The mixture was refluxed under heating for 2 hours. After completion of the reaction, ethanol was distilled off under reduced pressure, and water was added to the residue. The mixture was extracted with dichloromethane. The extract was dried over an hydrous sodium sulfate, and the solvent was distilled off to obtain [4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone as a yellow oily substance.

후처리

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 2 hours
  3. distillationwas distilled off under reduced pressure, and water
  4. additionwas added to the residue
  5. extractionThe mixture was extracted with dichloromethane
  6. dry with materialThe extract was dried over an hydrous sodium sulfate
  7. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-5ddb47e1406345ea80569a0f87ba740d
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05288727

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