Azobisisobutyronitrile → Ethyl maleimide t-butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate 3-hydroxypropyl bicyclo[2,2,2]oct-5-ene-2-carboxylate

HRID 1975895노트

반응식

HRID 1975895 반응식
[CH2:1]([C:3]1[C:4]([NH:6][C:7](=[O:9])[CH:8]=1)=[O:5])[CH3:2].[CH:10]12[CH2:17][CH2:16][CH:13]([CH:14]=[CH:15]1)[CH2:12][CH:11]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19].[CH:25]12[CH2:32][CH2:31][CH:28]([CH:29]=[CH:30]1)[CH2:27][CH:26]2[C:33]([O:35][CH2:36][CH2:37][CH2:38][OH:39])=[O:34].N(C(C)(C)C#N)=NC(C)(C)C#N>O1CCCC1>[CH2:1]([C:3]1[C:4]([NH:6][C:7](=[O:9])[CH:8]=1)=[O:5])[CH3:2].[CH:10]12[CH2:17][CH2:16][CH:13]([CH:14]=[CH:15]1)[CH2:12][CH:11]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19].[CH:25]12[CH2:32][CH2:31][CH:28]([CH:29]=[CH:30]1)[CH2:27][CH:26]2[C:33]([O:35][CH2:36][CH2:37][CH2:38][OH:39])=[O:34]

참가 물질

6

반응물 4

HCID 6547AzobisisobutyronitrileHCID 14671028Ethyl maleimideHCID 18413667t-Butyl bicyclo[2,2,2]oct-5-ene-2-carboxylateHCID 229870623-Hydroxypropyl bicyclo[2,2,2]oct-5-ene-2-carboxylate

생성물 1

HCID 131722531Ethyl maleimide t-butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate 3-hydroxypropyl bicyclo[2,2,2]oct-5-ene-2-carboxylate수율 75%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl maleimide (1 mol.), t-butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate (0.5 mol.) and 3-hydroxypropyl bicyclo[2,2,2]oct-5-ene-2-carboxylate (0.5 mol) were dissolved in 50 g to 300 g of tetrahydrofuran (THF), 2 g to 15 g of 2,2′-azobisisobutyronitrile (AIBN) was added thereto, and the resulting solution was reacted at a temperature between 60° C. and 70° C. in a nitrogen atmosphere for 10 hours. After a high molecular weight was achieved by the reaction, the resultant product was precipitated in an ethyl ether or hexane solvent. The gathered precipitate was dried, and the desired poly(ethyl maleimide/t-butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate/bicyclo[2,2,2]oct-5-ene-2-carboxylate) polymer was obtained at a yield of 75%

후처리

  1. customthe resulting solution was reacted at a temperature between 60° C. and 70° C. in a nitrogen atmosphere for 10 hours
  2. customAfter a high molecular weight was achieved by the reaction
  3. customthe resultant product was precipitated in an ethyl ether or hexane solvent
  4. customThe gathered precipitate was dried
  5. customwas obtained at a yield of 75%

출처 및 근거

ORD 기록
ord-562ac457a4964c3aac994e6d27e8b4d6
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06225020B1

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