Hydrochloric Acid → 2-(Piperidin-4-yl)benzonitrile hydrochloride
반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=2[C:16]#[N:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=2[C:16]#[N:17])[CH2:10][CH2:9]1참가 물질
4
실험 절차
To a solution of 2-(1-tertbutoxycarbonylpiperidin-4-yl)benzonitrile (1.7 g, 5.9 mmol) in ethyl acetate (˜50 ml), cooled to 0° C. was added hydrogen chloride gas, bubbled vigorously for 5 minutes. The reaction mixture was stirred for 10 minutes at 0+ C., purged with argon and concentrated. Flushing with ethyl acetate×3 and concentration gave 2-(piperidin-4-yl)benzonitrile hydrochloride;
후처리
- custombubbled vigorously for 5 minutes
- custom, purged with argon
- concentrationconcentrated
- customFlushing with ethyl acetate×3 and concentration
출처 및 근거
- ORD 기록
- ord-cdb67afec27b4eb6a45fbae0a0acb094
- 출처 데이터셋
- uspto-grants-2001_05
- 특허 번호
- US06228870B1
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