Sodium Hydroxide → 6-(methylsulfanyl)-1H-indole-2-carboxylic acid

HRID 1976732노트

반응식

HRID 1976732 반응식
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([S:14][CH3:15])[CH:8]=2)=[O:4].[OH-].[Na+]>>[CH3:15][S:14][C:9]1[CH:8]=[C:7]2[C:12]([CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 4715405202584-20-1

생성물 1

HCID 39071736-(methylsulfanyl)-1H-indole-2-carboxylic acid수율 91%

실험 절차

A mixture of methyl-6-methylsulfanyl-1H-indole-2-carboxylate (11.2 g, 51 mmol) and 2N NaOH (125 ml) was heated to reflux temperature for 30 minutes. The clear solution was cooled, and extracted with EtOAc. The aqueous fraction was acidified with concentrated HCl to pH=1, and the precipitate which formed, was filtered and dried to give 6-Methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 91.0%).

후처리

  1. temperaturewas heated
  2. temperatureto reflux temperature for 30 minutes
  3. temperatureThe clear solution was cooled
  4. extractionextracted with EtOAc
  5. customthe precipitate which formed
  6. filtrationwas filtered
  7. customdried

출처 및 근거

ORD 기록
ord-496beb0490f54e3eaf4c7848af5695b0
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06228877B1

반응 노트

불러오는 중…