Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-(Pentafluoroethyl)benzonitrile | HCID 14774185 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid | HCID 23067883 | 85% |
반응 단계
A mixture of 4-pentafluoroethyl-benzonitrile (2.98 g, 13.5 mmol) and potassium hydroxide (3.03 g, 54.0 mmol) in water (40 mL) and ethanol (20 mL) was heated at reflux for 16 h. After cooling, the solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) produced the title compound (2.76 g, 85%). White solid, MS (ISP) 238.9 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745477B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0130db70885d4824aae1fb9cc2481a2d |
| 출처 메모 | uspto-grants-2010_06 |