Glyoxylic Acid → 58207-08-2

HRID 1977491노트

반응식

HRID 1977491 반응식
[C:1]([OH:5])(=[O:4])[CH:2]=O.C([N:15](CC1C=CC(OC)=CC=1)C)C1C=CC(OC)=CC=1.[C:26]1([CH:32]=[CH:33]B(O)O)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C1(C)C=CC=CC=1>[NH2:15][CH:2](/[CH:33]=[CH:32]/[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:1]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 760Glyoxylic AcidHCID 27343812-Phenylvinylboronic acidHCID 19866082HCID 19866082, 화합물

생성물 1

HCID 588530958207-08-2수율 202.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred solution of glyoxylic acid (110 mg, 1.2 mmol) in toluene (12 mL) was added di-(p-anisyl)-methylamine (291 mg, 1.2 mmol) in one portion. After 1 min, 2-phenylethenyl boronic acid (177 mg, 1.2 mmol) was added and the reaction mixture was stirred vigorously for 12 hours. The precipitated product was isolated by filtration, washed with dichloromethane (15 mL), toluene (10 mL) and dried under vacuum to give the expected product (430 mg, 89% yield). 1H-NMR (360 MHz, CD3OH) d 6.8-7.5 (m, 13H), 6.60 (d, J=15.5 Hz, 1H), 6.25 (dd, J=15.5 Hz, 9.5 Hz, 1H), 5.49 (s, 1H), 4.00 (d, J=9.5 Hz, 1H), 3.75 (s, 6H), 2.3 (s, 1H).

후처리

  1. customThe precipitated product was isolated by filtration
  2. washwashed with dichloromethane (15 mL), toluene (10 mL)
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-0bfb312c17aa449aa1541e20b4aa9604
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232467B1

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