2-Bromopyridine → 2-fluoro-N-(2-pyridyl)acetanilide

반응식

[F:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1>>[F:1][CH2:2][C:3]([N:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

참가 물질

반응물 2

HCID 79732-Bromopyridine

HCID 95042-Fluoro-N-phenylacetamide

생성물 1

HCID 219935112-fluoro-N-(2-pyridyl)acetanilide수율 75.2%

실험 절차

Using 2-fluoroacetanilide (4.6 g) and 2-bromopyridine (9.5 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1.5) produced 2-fluoro-N-(2-pyridyl)acetanilide (5.2 g, crude product) as a red oil.

후처리

customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1.5)

출처 및 근거

ORD 기록: ord-742831b86bf34a6ca0b650a7d420922f
출처 데이터셋: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06235730B1

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