Hydrogen Bromide → 1-(1-Bromo-2-methylpropyl)-4-chlorobenzene

HRID 1977719

반응식

HRID 1977719 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6](O)[CH:7]([CH3:9])[CH3:8])=[CH:4][CH:3]=1.[BrH:13]>>[Br:13][CH:6]([C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:7]([CH3:9])[CH3:8]

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 202426Benzenemethanol, 4-chloro-alpha-(1-methylethyl)-

생성물 1

HCID 217034861-(1-Bromo-2-methylpropyl)-4-chlorobenzene

실험 절차

A mixture of p-chloro-α-isopropylbenzyl alcohol (33.08 g) in 48% hydrobromic acid (330 mL) is stirred at room temperature for 1 hour and extracted with hexanes. The combined organic extracts are washed sequentially with water, saturated sodium hydrogen carbonate solution and water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a yellow oil (42.98 g) which is identified by NMR spectral analysis.

후처리

  1. extractionextracted with hexanes
  2. washThe combined organic extracts are washed sequentially with water, saturated sodium hydrogen carbonate solution and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-ade00b8df7ff44f3a12cdf2e2885c98d
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235754B1

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