Trifluoroacetic anhydride → HCID 22880382, 화합물

HRID 1978087노트

반응식

HRID 1978087 반응식
[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([OH:8])=[O:7])([OH:3])=[O:2].F[C:15](F)(F)C(OC(=O)C(F)(F)F)=O>>[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([O:8][CH3:15])=[O:7])([OH:3])=[O:2]

참가 물질

3

반응물 2

HCID 9845Trifluoroacetic anhydrideHCID 10845347Disodium (2S,3R)-2-hydroxy-3-isobutylsuccinate

생성물 1

HCID 22880382HCID 22880382, 화합물

실험 절차

4.48 g of 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoic acid were stirred under nitrogen in 10 ml of trifluoroacetic anhydride for 1.5 hours. The solvent was evaporated and the residue was dissolved in 20 ml of dry methanol and stirred overnight at room temperature. The solvent was evaporated to give 5.3 g of methyl 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoate in the form of an orange oil.

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in 20 ml of dry methanol
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-6efa1773777f44bab4707db4573dc354
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235787B1

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