Hydrochloric Acid → N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

HRID 1978461노트

반응식

HRID 1978461 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:30]>C(O)C>[ClH:30].[ClH:30].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21994006N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

생성물 1

HCID 21994005N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a solution of 479 mg (1.18 mmol) of N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4 mM) of 4N-HCl/methnol and the mixture was stirred at room temperature for several minutes. The solvent was then distilled off under reduced pressure and the residue was diluted with ethanol and diethyl ether. The resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound.

후처리

  1. distillationThe solvent was then distilled off under reduced pressure
  2. additionthe residue was diluted with ethanol and diethyl ether
  3. filtrationThe resulting crystals were collected by filtration
  4. washrinsed with ethanol and diethyl ether

출처 및 근거

ORD 기록
ord-b19b43e1783142e29dc42b5848319df9
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235731B1

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