Hydrochloride methanol → n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978464

반응식

HRID 1978464 반응식
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:32].CO>C(O)C>[ClH:32].[ClH:32].[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 21993902N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

생성물 1

HCID 21993901n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 414 mg (0.95 mM) of N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (9 ml) was added 1.0 ml (4 mM) of 4N-HCl/methanol and the mixture was stirred at room temperature for 30 minutes. The resulting crystals were collected by filtration and rinsed with ethanol and ether to provide the title compound.

후처리

  1. filtrationThe resulting crystals were collected by filtration
  2. washrinsed with ethanol and ether

출처 및 근거

ORD 기록
ord-2ae5c4ed864d4d1690729d5a8fd1e0a6
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235731B1

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