Hydrochloric Acid → HCID 21993733, 화합물

HRID 1978514노트

반응식

HRID 1978514 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][N:13]([C:17]([CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])=[O:18])[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:35]>C(O)C>[ClH:35].[ClH:35].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][N:13]([C:17]([CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])=[O:18])[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21993734HCID 21993734, 화합물

생성물 1

HCID 21993733HCID 21993733, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 1.00 g (2.1 mmol.) of N-[4-(3-phenylpropan-1-yl)-2,3,5,6-tetrahydro-7H-1,4-diazepin-1-ylcarbonylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (10 ml) was added, at room temperature, 1 ml (12 mmol.) of 12N hydrochloric acid. The mixture was stirred for several minutes, followed by concentration under reduced pressure. To the resulting crystals was added diethyl ether. The crystals were collected by filtration, which were washed with ethanol and diethyl ether to give the object product as orange crystals. The yield was 0.996 g (86%).

후처리

  1. concentrationfollowed by concentration under reduced pressure
  2. additionTo the resulting crystals was added diethyl ether
  3. filtrationThe crystals were collected by filtration, which
  4. washwere washed with ethanol and diethyl ether

출처 및 근거

ORD 기록
ord-672f393bfafc4a488ecf80d7e10afd13
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235731B1

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