Ethanolamine → 2-{[(4-Tert-butylphenyl)methyl]amino}ethan-1-ol

HRID 19786

반응식

HRID 19786 반응식
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:13]([CH2:15][NH2:16])[OH:14].[BH4-].[Na+]>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:16][CH2:15][CH2:13][OH:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 700EthanolamineHCID 703244-tert-ButylbenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 288330382-{[(4-Tert-butylphenyl)methyl]amino}ethan-1-ol수율 93%

실험 절차

The title compound was synthesized in analogy to example S3-C using 4-tert-butylbenzaldehyde (1000 mg, 6.17 mmol), ethanolamine (371 μl, 6.17 mmol) and sodium borohydride (350 mg, 9.25 mmol). The desired product (1190 mg, 93%) was isolated without further purification as a colorless oil. MS (ISP) 208.3 (M+H)+.

출처 및 근거

ORD 기록
ord-62d199f6d737452d93ec52c8e6f55004
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745477B2

연결된 노트

불러오는 중…