Methyl 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate → 7-Bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11](=[O:13])(=[O:12])[CH2:10][CH2:9][C:8]([C:14]([O:16]C)=[O:15])=[CH:7][C:6]=2[CH:18]=1>COCCOC.Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11](=[O:13])(=[O:12])[CH2:10][CH2:9][C:8]([C:14]([OH:16])=[O:15])=[CH:7][C:6]=2[CH:18]=1참가 물질
4
실험 절차
A solution of methyl 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (700 mg) in 1,2-dimethoxyethane (15 ml) and 6N hydrochloric acid was refluxed for 18 hours and cooled to room temperature. The solvent was evaporated under reduced pressure to give colorless crystals, which were collected by filtration. The crystals were washed with water, 2-propanol and diisopropylether to give colorless crystals of 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (634 mg).