참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromo-2-chlorophenol | HCID 19859 | — |
| 반응물 | 1-(2-Chloroethoxy)propane | HCID 123506 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Bromo-2-chloro-1-(2-propoxyethoxy)benzene | HCID 21995684 | — |
반응 단계
To a solution of 4-bromo-2-chlorophenol (10 g) in DMF (200 ml) were added at room temperature potassium carbonate (9.99 g), sodium iodide (7.95 g) and 2-chloroethylpropylether (6.7 ml), and the mixture was stirred at 90° C. for 24 hours. To the mixture was added water, and the mixture was extracted with hexane. The organic layer was washed with water, 1N sodium hydroxide solution and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give pale yellow oil of 4-bromo-2-chloro-1-(2-propoxyethoxy)benzene (14.91 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06235771B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_05 |
|---|
| ORD ID | ord-3e6702724b0d479692c3047928c7e0f3 |
|---|
| 출처 메모 | uspto-grants-2001_05 |
|---|
