反应详情

温度

90 °C

To a solution of 4-bromo-2-chlorophenol (10 g) in DMF (200 ml) were added at room temperature potassium carbonate (9.99 g), sodium iodide (7.95 g) and 2-chloroethylpropylether (6.7 ml), and the mixture was stirred at 90° C. for 24 hours. To the mixture was added water, and the mixture was extracted with hexane. The organic layer was washed with water, 1N sodium hydroxide solution and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give pale yellow oil of 4-bromo-2-chloro-1-(2-propoxyethoxy)benzene (14.91 g).

1. extractionthe mixture was extracted with hexane
2. washThe organic layer was washed with water, 1N sodium hydroxide solution and saturated brine
3. dry with materialdried with magnesium sulfate
4. concentrationconcentrated under reduced pressure