Water → 1-Bromo-4-(2-butoxyethoxy)benzene

HRID 1978693노트

반응식

HRID 1978693 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=1.[H-].[Na+].I[CH2:15][CH2:16][CH2:17][CH3:18].O>CN(C=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][O:9][CH2:15][CH2:16][CH2:17][CH3:18])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 10962Butyl iodideHCID 24758Sodium hydrideHCID 991682-(p-Bromophenoxy)ethanol

생성물 1

HCID 111848761-Bromo-4-(2-butoxyethoxy)benzene수율 63.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In DMF (150 ml) was dissolved 2-(4-bromophenoxy)-1-ethanol (15.7 g). To the mixture was added under ice-cooling 65% sodium hydride (4.3 g),and the mixture was stirred at room temperature for 2 hours. To the mixture was added dropwise iodobutane (17.3 g), and the mixture was stirred for 2 hours. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=4/1) to give 1-bromo-4-(2-butoxyethoxy)benzene (12.6 g).

후처리

  1. additionTo the mixture was added under ice-
  2. stirringthe mixture was stirred for 2 hours
  3. extractionthe mixture was extracted with ethyl acetate
  4. washwashed with saturated brine
  5. dry with materialdried with magnesium sulfate
  6. customUnder reduced pressure, the solvent was evaporated
  7. customthe residue was purified with silica gel column chromatography (hexane/ethyl acetate=4/1)

출처 및 근거

ORD 기록
ord-68b1e8a2020c4591abbcbbc54a8c7028
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235771B1

반응 노트

불러오는 중…