Sodium Iodide → 1-Bromo-2-(2-propoxyethoxy)benzene

HRID 1978723노트

반응식

HRID 1978723 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].Br[CH2:18][CH2:19][O:20][CH2:21][CH2:22][CH3:23]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:18][CH2:19][O:20][CH2:21][CH2:22][CH3:23]

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 72442-BromophenolHCID 11430Potassium CarbonateHCID 27341841-(2-Bromoethoxy)propane

생성물 1

HCID 219958661-Bromo-2-(2-propoxyethoxy)benzene

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

In DMF (120 ml) was dissolved 2-bromophenol (12 g), and to the solution were added potassium carbonate (14.4 g) and sodium iodide (10.4 g). To the mixture was added 2-bromoethylpropylether (10.4 ml), and the mixture was stirred at 90° C. for 16 hours. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1) to give 1-bromo-2-(2-propoxyethoxy)benzene (14.4 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washwashed with saturated brine
  3. dry with materialdried with magnesium sulfate
  4. customUnder reduced pressure, the solvent was evaporated
  5. customthe residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1)

출처 및 근거

ORD 기록
ord-2389317e888a452fad20d5d8933e7411
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235771B1

반응 노트

불러오는 중…