Hydrochloric Acid → 2-(4-Chlorophenoxy)acetaldehyde

HRID 1978804노트

반응식

HRID 1978804 반응식
C[O:2][CH:3](OC)[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.Cl>CC(C)=O>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]=[O:2])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 15510276HCID 15510276, 화합물

생성물 1

HCID 114806982-(4-Chlorophenoxy)acetaldehyde수율 24%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Chlorophenoxyacetaldehyde dimethylacetal (1.0 g) was dissolved in acetone (10 ml), to which 2N hydrochloric acid (1.0 g) was added, and the mixture was heated under reflux for 8 hours. After the reaction mixture was concentrated, water was added and the mixture was extracted with ethyl acetate. The extracts were dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 4-chlorophenoxyacetaldehyde as a crude product.

후처리

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 8 hours
  4. concentrationAfter the reaction mixture was concentrated
  5. additionwater was added
  6. extractionthe mixture was extracted with ethyl acetate
  7. dry with materialThe extracts were dried over anhydrous sodium sulfate
  8. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-049cc2a03c6a4da5831507c9f1fa3d8e
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239077B1

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