Propylamine → HCID 135537129, 화합물

HRID 1978867노트

반응식

HRID 1978867 반응식
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 178458304HCID 178458304, 화합물

생성물 1

HCID 135537129HCID 135537129, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)-pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on washing with water. The residue was recrystallized from isopropanol:water to yield the title compound, 0.56 g, m.p. 172-3° C.

후처리

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-621a7352cd934cf3a2398eeb0b01d0d7
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239136B1

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