4-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid, methyl ester → 4-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid

HRID 1979168

반응식

HRID 1979168 반응식
[O:1]=[C:2]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH2:3][CH2:4][C:5]([O:7]C)=[O:6]>Cl>[O:1]=[C:2]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

참가 물질

3

반응물 1

HCID 120568844-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid, methyl ester

생성물 1

HCID 230052404-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid수율 99%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

In a manner similar to Example 4, Step (b), 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid, methyl ester (1.34 g, 0.00398 mol) was refluxed in 6 M aqueous hydrochloric acid (24 mL) to give 1.27 g of 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as an 80% pure solid. A portion (0.059 g) of the material was purified by chromatography on silica gel (7 g, 230-400 mesh), eluting with dichloromethane (15×10 mL); dichloromethanemethanol (15:1; 16×10 mL) to give 0.0476 g of pure 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as an off-white solid; mp 172-174° C.

출처 및 근거

ORD 기록
ord-014e80ec32204f6a8cc8350970e44ba7
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239288B1

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