Potassium Carbonate → N-Methyl-4-phenyl-4-piperidyl N-(8-trifluoromethyl-4-quinolyl)anthraniloyloxyacetate

HRID 1979728

반응식

HRID 1979728 반응식
Cl.Cl[CH2:3][C:4]([O:6][C:7]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5].[Na].[F:21][C:22]([F:44])([F:43])[C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[C:32]=1[N:31]=[CH:30][CH:29]=[C:28]2[NH:33][C:34]1[C:35](=[CH:39][CH:40]=[CH:41][CH:42]=1)[C:36]([OH:38])=[O:37].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:43][C:22]([F:21])([F:44])[C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[C:32]=1[N:31]=[CH:30][CH:29]=[C:28]2[NH:33][C:34]1[C:35](=[CH:39][CH:40]=[CH:41][CH:42]=1)[C:36]([O:38][CH2:3][C:4]([O:6][C:7]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5])=[O:37]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 37541Floctafenic acidHCID 5360545SodiumHCID 20438865N-methyl-4-phenyl-4-piperidyl chloroacetate hydrochloride

생성물 1

HCID 16206495N-Methyl-4-phenyl-4-piperidyl N-(8-trifluoromethyl-4-quinolyl)anthraniloyloxyacetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1.52 g of N-methyl-4-phenyl-4-piperidyl chloroacetate hydrochloride, 1.77 g of the sodium salt of N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid and 0.7 g of potassium carbonate in 10 ml of dimethylformamide was stirred for 48 hours at 20°-25° C. Upon completion of the reaction, the inorganic salts were filtered off. The solution was evaporated to dryness and treated with water, and the solid collected by filtration. This solid was then refluxed with hexane, filtered and recrystallized from hexane to provide the title compound. M.p. 144°-145° C., yield 1 g (35%).

후처리

  1. customUpon completion of the reaction
  2. filtrationthe inorganic salts were filtered off
  3. customThe solution was evaporated to dryness
  4. additiontreated with water
  5. filtrationthe solid collected by filtration
  6. temperatureThis solid was then refluxed with hexane
  7. filtrationfiltered
  8. customrecrystallized from hexane

출처 및 근거

ORD 기록
ord-d371c46e99a743ea9f658f34ff924290
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04482561

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