Dimethylformamide → 78484-03-4

HRID 1979775노트

반응식

HRID 1979775 반응식
[OH:1][CH:2]([CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:19][CH2:18]1)[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][C:9](=[O:15])[NH:10]2.C[I:30].[CH3:31]N(C)C=O>CC(C)=O>[I-:30].[C:23]1([CH:20]2[CH2:19][CH2:18][N+:17]([CH2:16][CH:2]([OH:1])[CH2:3][O:4][C:5]3[CH:14]=[CH:13][CH:12]=[C:11]4[C:6]=3[CH2:7][CH2:8][C:9](=[O:15])[NH:10]4)([CH3:31])[CH2:22][CH2:21]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 12783759HCID 12783759, 화합물

생성물 1

HCID 306101478484-03-4

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2.0 Grams of 5-[2-hydroxy-3-(4-phenyl-1-piperidyl)propoxy]-3,4-dihydrocarbostyril and 3 g of methyl iodide were mixed with 30 ml of dimethylformamide and the mixture was stirred at 50°-60° C. for 5 hours. The reaction mixture was concentrated under a reduced pressure and to the residue thus obtained was added 50 ml of acetone and stirred. The precipitates thus formed were collected by filtration and washed with acetone, then recrystallized from methanol-ethanol to obtain 1.7 g of 4-phenyl-1-[2-hydroxy-3-(2-oxo-1,2,3,4-tetrahydroquinolin-5-yloxy)propyl]-1-methylpiperidiniumiodide as in the form of colorless powdery substance. Melting point: 242°-243° C.

후처리

  1. concentrationThe reaction mixture was concentrated under a reduced pressure and to the residue
  2. customthus obtained
  3. stirringstirred
  4. customThe precipitates thus
  5. customformed
  6. filtrationwere collected by filtration
  7. washwashed with acetone
  8. customrecrystallized from methanol-ethanol

출처 및 근거

ORD 기록
ord-5efdf3e0154d4c9eb72d29f9c0f4f1e9
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04482560

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