Methyl iodide → HCID 20437408, 화합물

HRID 1980090노트

반응식

HRID 1980090 반응식
[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH3:24][I:25]>CO>[I-:25].[OH:1][CH:2]([CH2:9][NH:10][S:11]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][N+:4]1([CH3:24])[CH2:8][CH2:7][CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 20437405HCID 20437405, 화합물

생성물 1

HCID 20437408HCID 20437408, 화합물수율 545.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1-[2-hydroxy-3-(1-naphthalenesulphonamido)propyl]pyrrolidine (2 g; 0.0005 mol) in methanol (50 ml) was added methyl iodide (6.9 g; 0.05 mol). The mixture was left at room temperature 12 hours. The reaction mixture was evaporated to dryness and the residue was recrystallized from ethanol (20 ml) to obtain the product (1.3 g).

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customthe residue was recrystallized from ethanol (20 ml)

출처 및 근거

ORD 기록
ord-dfe7be1f650f49aaa7511649034dfcf6
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04485108

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