(5-bromo-1-benzofuran-2-yl)(phenyl)methanone → (5-Bromo-1-benzofuran-2-yl)(phenyl)methanol

HRID 1980102노트

반응식

HRID 1980102 반응식
[BH4-].[Na+].[C:3]([C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:14]=2[CH:15]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O.O1CCOCC1>[Br:20][C:17]1[CH:18]=[CH:19][C:13]2[O:12][C:11]([CH:3]([C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[OH:10])=[CH:15][C:14]=2[CH:16]=1

참가 물질

5

반응물 2

HCID 801609(5-bromo-1-benzofuran-2-yl)(phenyl)methanoneHCID 4311764Sodium borohydride

생성물 1

HCID 3067860(5-Bromo-1-benzofuran-2-yl)(phenyl)methanol

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

4 g of sodium borohydride dissolved in the minimum quantity of water are slowly added at ambient temperature to 8.5 g of 2-benzoyl-5-bromobenzofuran in 50 ml of dioxane. When the addition is finished, the mixture is kept stirring at ambient temperature for a further 3 hours. The solvent is removed under reduced pressure, the residue is redissolved in 50 ml of water, and extracted with ethyl ether. The ether phase is dried with anhydrous sodium sulphate, evaporated to dryness, and leaves a residue which on crystallising from cyclohexane has a M.P. of 56°-58° C.

후처리

  1. additionWhen the addition
  2. customThe solvent is removed under reduced pressure
  3. dissolutionthe residue is redissolved in 50 ml of water
  4. extractionextracted with ethyl ether
  5. dry with materialThe ether phase is dried with anhydrous sodium sulphate
  6. customevaporated to dryness
  7. customleaves a residue which
  8. customon crystallising from cyclohexane

출처 및 근거

ORD 기록
ord-3b7de48b68794ecca5280b1b0fe71902
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04485112

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