4-tert-Butylbenzenesulfonamide → N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide

HRID 1980163

반응식

HRID 1980163 반응식
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[C:28]([C:32]1[CH:37]=[CH:36][C:35]([S:38]([NH2:41])(=[O:40])=[O:39])=[CH:34][CH:33]=1)([CH3:31])([CH3:30])[CH3:29]>N1C=CC=CC=1>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:41][S:38]([C:35]2[CH:36]=[CH:37][C:32]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:33][CH:34]=2)(=[O:39])=[O:40])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 2228724-tert-ButylbenzenesulfonamideHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

생성물 1

HCID 20437349N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 10.8 g. of p-tert-butylbenzenesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and evaporated. The residue was partitioned between 1N hydrochloric acid and CH2Cl2 and the organic layer was separated, washed with water, dried (MgSO4), and evaporated. Crystallization of the residual glass from CH2Cl2 hexane afforded a white solid, melting point 173°-176° C.

후처리

  1. temperatureunder reflux for 2 hours
  2. customevaporated
  3. customThe residue was partitioned between 1N hydrochloric acid and CH2Cl2
  4. customthe organic layer was separated
  5. washwashed with water
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customCrystallization of the residual glass from CH2Cl2 hexane
  9. customafforded a white solid, melting point 173°-176° C.

출처 및 근거

ORD 기록
ord-6c61759175584884a699b25894682d7d
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04485105

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