Methane → HCID 20402691, 화합물

HRID 1980262노트

반응식

HRID 1980262 반응식
Cl.[NH2:2][C:3]1[C:4]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:8])[NH:6][CH:7]=1.C.[Cl:18][CH2:19][C:20](Cl)=[O:21].[OH-].[Na+]>O>[C:9]([C:4]1[C:3]([NH:2][C:20](=[O:21])[CH2:19][Cl:18])=[CH:7][NH:6][C:5]=1[CH3:8])(=[O:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

6

반응물 4

HCID 297MethaneHCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 3042146Methanone, (4-amino-2-methyl-1H-pyrrol-3-yl)phenyl-, monohydrochloride

생성물 1

HCID 20402691HCID 20402691, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-Amino-3-benzoyl-2-methylpyrrole hydrochloride (0.019 mole) was dissolved in water (40 ml) and the solution was treated with charcoal (0.1 g) and filtered. Toluene was added and chloroacetylchloride (0.067 mole) and aqueous NaOH (58.1 ml, 20% w/v) were added separately but simultaneously during 1 hour to the stirred two-phase solution. The reaction mixture was maintained under an inert atmosphere and at room temperature for 1.5 hour. The compound of the title which spontaneously crystallized out of the reaction mixture, was collected by filtration.

후처리

  1. filtrationfiltered
  2. additionToluene was added
  3. customThe compound of the title which spontaneously crystallized out of the reaction mixture
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-501609bdceec4c06a5f8c4e9e7c1323c
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04508730

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