Water → Methyl [2-(triphenylmethoxy)ethyl]carbamodithioate

HRID 1980369노트

반응식

HRID 1980369 반응식
[CH3:1][S:2][C:3](=[S:8])[NH:4][CH2:5][CH2:6][OH:7].[C:9]1([C:15](Cl)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O>N1C=CC=CC=1>[CH3:1][S:2][C:3](=[S:8])[NH:4][CH2:5][CH2:6][O:7][C:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6456Trityl chlorideHCID 13277332Methyl (2-hydroxyethyl)carbamodithioate

생성물 1

HCID 54058214Methyl [2-(triphenylmethoxy)ethyl]carbamodithioate수율 75.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of N-(2-hydroxyethyl)dithiocarbamic acid methyl ester (7.5 g) in pyridine (40 ml) is added triphenylmethyl chloride (15 g), and the mixture is left to stand overnight at room temperature. The reaction mixture is poured into water and extracted with ethyl acetate. The extract is washed with diluted hydrochloric acid and water, dried and concentrated to remove the solvent. The residue is crystallized from a mixture of dichloromethane and ether to give N-(2-triphenylmethoxyethyl)dithiocarbamic acid methyl ester (14.73 g).

후처리

  1. waitthe mixture is left
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with diluted hydrochloric acid and water
  4. customdried
  5. concentrationconcentrated
  6. customto remove the solvent
  7. customThe residue is crystallized from a mixture of dichloromethane and ether

출처 및 근거

ORD 기록
ord-25d16449d4554ffea55143854dfd5ddc
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04508909

반응 노트

불러오는 중…