Hydroxyamine hydrochloride → 3,7-Dichloroquinoline-8-carbonitrile

HRID 1980754노트

반응식

HRID 1980754 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH:13](Cl)Cl.Cl.[NH2:17]O.C([O-])=O.[Na+]>C(O)=O.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]#[N:17]

참가 물질

6

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 2723810Sodium FormateHCID 130907853,7-Dichloro-8-(dichloromethyl)quinoline

생성물 1

HCID 130907923,7-Dichloroquinoline-8-carbonitrile수율 78.5%

시약·촉매·용매 2

HCID 284Formic Acid용매HCID 962Water용매

실험 절차

28.1 parts by weight of the 3,7-dichloro-8-dichloromethylquinoline thus obtained, 6.95 parts by weight of hydroxylamine hydrochloride and 13.6 parts by weight of sodium formate in 200 ml of formic acid and 60 ml of water were stirred for 12 hours at 100° C., the reaction solution was poured onto ice, the precipitated solid was filtered off under suction, washed neutral with water and dried. 19 parts by weight of 3,7-dichloro-8-cyanoquinoline of melting point 222° C. were obtained. Yield: 78.5% of theory.

후처리

  1. additionthe reaction solution was poured onto ice
  2. filtrationthe precipitated solid was filtered off under suction
  3. washwashed neutral with water
  4. customdried

출처 및 근거

ORD 기록
ord-3ee7a7a981954f159dd551750df7ed5e
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04511393

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