Sodium Hydroxide → 5-Benzoyl-1-methyl-1h-pyrrole-2-carboxylic acid

HRID 1980953노트

반응식

HRID 1980953 반응식
[CH3:1][N:2]1[C:6]([C:7](=[O:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]1[C:15]([O:17]C)=[O:16].[OH-].[Na+]>CO>[CH3:1][N:2]1[C:6]([C:7](=[O:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]1[C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12897104Methyl 1-Methyl-5-benzoylpyrrole-2-carboxylate

생성물 1

HCID 128971035-Benzoyl-1-methyl-1h-pyrrole-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 1-methyl-5-benzoylpyrrole-2-carboxylate (0.78 g.) was heated on a steam bath for 1 hour with 40 ml. of 1N sodium hydroxide and 20 ml. of methanol. The reaction mixture was cooled to room temperature, extracted with ether, made acid with conc. hydrochloric acid and 1-methyl-5-benzoylpyrrole-2-carboxylic acid recovered by filtration (0.47 g., m.p. 178°-181° C.). Recrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.).

후처리

  1. extractionextracted with ether
  2. filtrationrecovered by filtration (0.47 g., m.p. 178°-181° C.)
  3. customRecrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.)

출처 및 근거

ORD 기록
ord-876abd5935df4884a53cd882014b72cd
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04511575

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