Methanethiol → N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

HRID 1981153노트

반응식

HRID 1981153 반응식
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:6][NH:7][C:8](=[NH:10])S.OCC[NH:14]C.CS.[CH:18]([OH:21])(C)[CH3:19]>C(O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[OH:21][CH2:18][CH2:19][N:7]([CH3:6])[C:8]([NH2:10])=[NH:14]

참가 물질

6

반응물 4

HCID 878MethanethiolHCID 3776IsopropanolHCID 80162-(Methylamino)ethanolHCID 178485225HCID 178485225, 화합물

생성물 1

HCID 20399896N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The above intermediate N-(2-hydroxyethyl)-N-methylquanidine sulfate was prepared as follows: A mixture containing 83.6 g of methyl isothiourea sulfate and 90 g of N-(2-hydroxyethyl)methylamine was heated on a steam bath under vacuum until no more methyl mercaptan was evolved. The solid remaining was boiled successively with hot isopropyl alcohol, hot absolute ethanol and then ether, and collected to yield 91 g of crystalline N-(2-hydroxyethyl)-N-methylguanidine sulfate.

후처리

  1. customether, and collected

출처 및 근거

ORD 기록
ord-f46e361758fc4810b257df44f7b9c0a6
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04512993

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