Water → 2-Amino-5-chloro-3-formyl-6-(n-propylamino)pyrazine
반응식
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4](Cl)[N:3]=1.[CH2:12]([NH2:15])[CH2:13][CH3:14].O>C(O)(C)C>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4]([NH:15][CH2:12][CH2:13][CH3:14])[N:3]=1참가 물질
5
실험 절차
In 1.2 ml of isopropyl alcohol there was dissolved 2-amino-5,6-dichloro-3-formylpyrazine (0.095 g) 0.0005 M) prepared in Step B, after which n-propylamine (32 g; 0.042 ml; 0.00055 M) was added, and the reaction mixture was stirred at room temperature for 20.5 hours. When water was added to the reaction mixture, product precipitated, was filtered, and dried (23 mg). Additional product precipitated, was filtered, and dried (46 mg). The product was recrystallized from ethyl acetate/hexane. Elemental Analysis for C8H11N4OCl.
후처리
- customprepared in Step B
- customprecipitated
- filtrationwas filtered
- customdried (23 mg)
- customAdditional product precipitated
- filtrationwas filtered
- customdried (46 mg)
- customThe product was recrystallized from ethyl acetate/hexane
출처 및 근거
- ORD 기록
- ord-1956e11224004063aae464e43b823485
- 출처 데이터셋
- uspto-grants-1985_04
- 특허 번호
- US04512991
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