Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxybenzaldehyde → 3-{3-[(Thiomorpholin-4-yl)methyl]phenoxy}propan-1-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Thiomorpholine | HCID 67164 | — |
| 반응물 | Phenol, 3-(4-thiomorpholinylmethyl)- | HCID 763337 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 1-Propanamine, 3-chloro-, hydrochloride | HCID 11469095 | — |
| 생성물 | 3-{3-[(Thiomorpholin-4-yl)methyl]phenoxy}propan-1-amine | HCID 20151506 | — |
반응 단계
By operating as described hereinabove, by reacting 0.2 mol of 3-hydroxybenzaldehyde with 0.4 mol of thiomorpholine in the presence of 0.2 mol of sodium borohydride (as in PREPARATION 1(a) 3-thiomorpholinomethylphenol is obtained, which, treated with an excess of 3-chloropropylamine hydrochloride in the presence of sodium hydride (as in PREPARATION 1(b), gives 3-(3-thiomorpholinomethylphenoxy)propylamine, in the form of an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04514408 |
| 출처 데이터셋 | uspto-grants-1985_04 |
| ORD ID | ord-56be3c1587b541558e18dc19dd2b92a3 |
| 출처 메모 | uspto-grants-1985_04 |